question_id stringlengths 24 24 | question stringlengths 13 215 | answer stringlengths 2 3.15k | relevant_passage_ids listlengths 1 157 | type stringclasses 4 values | snippets listlengths 1 121 |
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6415bc8d690f196b5100000f | What is the estimated reduction in time when using online genetic counseling? | The estimated reduction in the required time through online counseling is about 8%. | [
"26785833"
] | factoid | [
{
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"offsetInEndSection": 1645,
"text": "We estimated reduced time and costs by online counseling with about 8% and 10-12%, respectively. ",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26785833",
"endSection": "abstract"
}
] |
64163660690f196b5100001d | Is deflazacort more efficient than prednisone/prednisolone for the treatment of Duchenne muscular dystrophy? | Both daily prednisone and daily deflazacort were more effective | [
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"text": "Both daily prednisone and daily deflazacort were more effective than intermittent prednisone for the primary outcome (P < .001 for daily prednisone vs intermittent prednisone using a global test; P = .017 for daily deflazacort vs inter... |
6402bc2d201352f04a000005 | What are the targets of Mosunetuzumab? | Mosunetuzumab is an anti-CD20/CD3 T-cell engaging bispecific antibody, is being developed by Roche for the treatment of relapsed or refractory follicular lymphoma. | [
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"text": "They combine two different monospecific antigen-binding regions that target CD20 on B cells and engage T cells via CD3 in a 1:1 or 2:1 CD20:CD3 antigen binding fragment (Fab) format. The results of different phase 1 trials with BsAbs, in... |
64144200201352f04a000043 | Is anaphylaxis a results of mast cell activation? | anaphylaxis is a result of mast cell activation. | [
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"text": "Mast cells are important effector cells in allergic inflammatory reactions. The aggregation of the high-affinity IgE receptor (FcepsilonRI) on the surface of mast cells initiates a complex cascade of signaling events that ultimately leads ... |
6415c6b6690f196b51000015 | On which two clinical trials was the approval of Keytruda based? | Approval was based on two randomized, open-label, active-controlled trials demonstrating statistically significant improvements in progression-free survival (PFS) and overall survival (OS) for patients randomized to pembrolizumab compared with chemotherapy, namely KEYNOTE-024 and KEYNOTE-010. | [
"28835513"
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"text": "Approval was based on two randomized, open-label, active-controlled trials demonstrating statistically significant improvements in progression-free survival (PFS) and overall survival (OS) for patients randomized to pembrolizumab compar... |
64178e34690f196b51000021 | Is viltolarsen effective for the treatment of Duchenne muscular dystrophy? | Yes, viltolarsen is effective for the treatment of Duchenne muscular dystrophy. | [
"35634851",
"33285037",
"36401022"
] | yesno | [
{
"offsetInBeginSection": 0,
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"text": "Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the treatment of Duchenne muscular dystrophy (DMD)",
"beginSection": "abstract",
"document": "http://www.nc... |
640410d1201352f04a000012 | What is Wilkie's syndrome? | Wilkie's syndrome or Superior mesenteric artery (SMA) syndrome is a rare condition arising due to compression of the third part of the duodenum between the abdominal aorta and the superior mesenteric artery. | [
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] | summary | [
{
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"text": "BACKGROUND: The superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome, is one of the rarest causes of small bowel obstruction.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/32116... |
641461bb201352f04a000046 | What is a PROTAC? | A PROTAC is a heterobifunctional molecule that induces protein degradation by forming a ternary complex between a target protein and an E3 ubiquitin ligase. It consists of two ligands - one that binds to the target protein and the other that recruits the E3 ubiquitin ligase | [
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"3410059... | summary | [
{
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"text": "PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-degradation strategy that has emerged in recent years.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/35680848",
"endSection": ... |
6410f839201352f04a000032 | Can the concept of digital twins be applied in Precision Nutrition? | A "virtual digital twin" could serve to guide nutrition in a personalized manner. | [
"32770212"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 58,
"text": "The \"Virtual Digital Twins\" Concept in Precision Nutrition",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/32770212",
"endSection": "title"
},
{
"offsetInBeginSection": 559,
"offsetInEndS... |
63eef6edf36125a42600000d | What is the mechanism of action of Teclistamab? | Teclistamab is a bispecific antibody that targets CD3 and B cell maturation antigen (BCMA) and is being developed for the treatment of relapsed or refractory multiple myeloma. | [
"35749004",
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"36006441",
"35661166"
] | summary | [
{
"offsetInBeginSection": 0,
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"text": "BACKGROUND: Teclistamab is a T-cell-redirecting bispecific antibody that targets both CD3 expressed on the surface of T cells and B-cell maturation antigen expressed on the surface of myeloma cells.",
"beginSection": "abstract",
"d... |
640c8309201352f04a000024 | The diagnosis of cholestasis is based on the elevations seen in what liver function tests? | Cholestasis is due to an excess of bile in the liver and is often due to a biliary obstruction. There are disproportionate elevations in alkaline phosphatase (ALP) compared to alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Serum bilirubin. In Cholestasis of pregnancy, an elevation of the serum bile acids is often seen | [
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"text": "Cholestasis of pregnancy is the commonest liver disease unique to pregnancy and is characterized by pruritus in the mother in late pregnancy, without any skin rashes. This is accompanied by an elevation of the serum bile acids. ",
"beg... |
6415c599690f196b51000013 | Which company produces Keytruda? | Keytruda is produced by Merck & Co., Inc.. | [
"28835513"
] | factoid | [
{
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"text": "On October 24, 2016, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda; Merck & Co., Inc., https://www.merck.com) for treatment of patients with metastatic non-small cell lung cancer (mNSCLC) whose tumors express... |
64040edf201352f04a000011 | Based on clinical trial data, can pioglitazone delay cognitive impairment for people at risk for Alzheimer's disease? | No. Pioglitazone did not delay the onset of mild cognitive impairment. | [
"34146512"
] | yesno | [
{
"offsetInBeginSection": 3711,
"offsetInEndSection": 3793,
"text": "INTERPRETATION: Pioglitazone did not delay the onset of mild cognitive impairment.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/34146512",
"endSection": "abstract"
}
] |
6414638c201352f04a000047 | Cereblon (CRBN) has been identified as the target for what type of drug? | Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide. IMiDs bind to CRBN and recruit neo-substrates for their ubiquitination and proteasome-mediated degradation | [
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"text": "Cereblon is a well-known target of thalidomide and its derivatives.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36252444",
"endSection": "abstract"
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... |
63f9cdb033942b094c000012 | Does silencing of SRRM4 promote microexon inclusion? | No, silencing of SRRM4 does not promote microexon inclusion. | [
"33207694"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 80,
"text": "SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/33207694",
"endSection": "title"
},
{
"offsetInBeginSection": 12... |
63f03a20f36125a42600001c | Which drugs are included in the AZD7442? | AZD7442 is a combination of two long-acting monoclonal antibodies tixagevimab and cilgavimab. It has been authorized for the prevention and treatment of coronavirus disease 2019 (COVID-19). | [
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"35993765"
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{
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"text": "AZD7442, a combination of two long-acting monoclonal antibodies (tixagevimab [AZD8895] and cilgavimab [AZD1061]), has been authorized for the prevention and treatment of coronavirus disease 2019 (COVID-19). ",
"beginSection": "abstract... |
640ddd9d201352f04a000028 | What were the first 2 PD-1 inhibitors approved by the FDA in 2014? | The first two PD-1 inhibitors approved by the FDA in 2014 were nivolumab (Opdivo) and pembrolizumab (Keytruda). | [
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{
"offsetInBeginSection": 233,
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"text": "2 different programmed cell death protein 1 (PD-1) inhibitors, Nivolumab and Pembrolizumab.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/32984529",
"endSection": "abstract"
},
{
"offse... |
6414c4cf690f196b51000006 | What is the difference between dermatillomania and skin picking disorder? | Dermatillomania is also known as skin picking disorder (SPD). | [
"33808008"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 241,
"text": "Dermatillomania or skin picking disorder (SPD) is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual's health and quality of life... |
63eefa3bf36125a426000012 | What causes Japanese Spotted Fever? | Japanese Spotted Fever is caused by Rickettsia japonica. | [
"35507925",
"36016429",
"32863353"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 189,
"text": "Non-pathogenic Rickettsia species LON strains closely related to an agent of Japanese spotted fever (JSF), R. japonica, were isolated in Japan from Haemaphysalis longicornis ticks in 2001. ",
"beginSection": "abstract",
"document":... |
640dde93201352f04a000029 | What is the difference between PD-1 and PD-L1? | PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 (PD-L1) with its receptor, programmed cell death protein 1 (PD-1). PD-L1 is the receptor that binds to the PD-L1 protein | [
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"27903604",
"31876895",
"30519815",
"17924994",
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] | summary | [
{
"offsetInBeginSection": 14,
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"text": "To compare the real-world safety profile of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors between younger and older patients",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih... |
6410f8b2201352f04a000033 | What would be the benefits of using a virtual digital twin in nutrition? | A "virtual digital twin," could serve to guide nutrition in a personalized manner, thus revolutionizing the management of obesity and its comorbidities, and providing a pillar for healthy aging. | [
"32770212"
] | summary | [
{
"offsetInBeginSection": 559,
"offsetInEndSection": 968,
"text": "We herein discuss how genetic information combined with longitudinal metabolomic, immune, behavioral, and gut microbial parameters, and bioclinical variables could define a digital replica of oneself, a \"virtual digital twin,\" which co... |
64040af9201352f04a00000d | Is levosimendan effective for amyotrophic lateral sclerosis? | No. Levosimendan was not superior to placebo in maintaining respiratory function in a broad population with amyotrophic lateral sclerosis. Although levosimendan was generally well tolerated, increased heart rate and headache occurred more frequently with levosimendan than with placebo. | [
"34536404",
"31315908"
] | yesno | [
{
"offsetInBeginSection": 2720,
"offsetInEndSection": 3018,
"text": "INTERPRETATION: Levosimendan was not superior to placebo in maintaining respiratory function in a broad population with amyotrophic lateral sclerosis. Although levosimendan was generally well tolerated, increased heart rate and headach... |
6414c0f7690f196b51000001 | What are the clinical symptoms of an ornithine transcarbamylase deficiency? | The clinical symptoms of an ornithine transcarbamylase deficiency (OTC-D) can range from asymptomatic carrier state to severe neonatal presentation with hyperammonaemic encephalopathy. Common symptoms include extreme irritability, episodic vomiting and lethargy, protein avoidance, ataxia, Stage II coma, delayed physical growth, developmental delay, and seizures. | [
"36362876",
"17845164",
"3826955",
"3945292",
"36217298"
] | list | [
{
"offsetInBeginSection": 0,
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"text": "X-linked ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle defect. The disease severity ranges from asymptomatic carrier state to severe neonatal presentation with hyperammonaemic encephalopathy. ",
"beginSecti... |
63fa197c201352f04a000003 | How does SRSF11 contribute to metastasis potential of colorectal cancer? | SRSF11 exerts pro-metastatic effects in colorectal cancer by inhibiting the AS of HSPA12A pre-RNA. | [
"36394206"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 107,
"text": "Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36394206",
"endSection": "title"
},
{
... |
63eef60ef36125a42600000c | Olokizumab is tested for which disease? | Olokizumab, a monoclonal antibody against interleukin 6, improves outcomes of rheumatoid arthritis. | [
"34344706",
"36001712"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 240,
"text": "Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study... |
6413730e201352f04a00003f | Please summarize the function of Trophinin-associated protein (TROAP) | TROAP is a cytoplasmic protein that is required for spindle assembly and cell invasion. Its role in cancer is not yet fully understood, but it has been shown to regulate cell cycle and promote tumor progression through Wnt/β-Catenin signaling pathway in glioma cells. | [
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"29117881",
"30284652",
"34077623",
"30431120",
"7758945",
"35708862",
"34287099"
] | summary | [
{
"offsetInBeginSection": 1,
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"text": "ROAP regulates cell cycle and promotes tumor progression through Wnt/β-Catenin signaling pathway in glioma cells.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/34077623",
"endSection": "title"
},
... |
6410ed73201352f04a00002f | How does SRSF11 promote metastasis of colon cancer? | SRSF11 exerts pro-metastatic effects in CRC by inhibiting the AS of HSPA12A pre-RNA. | [
"36394206"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 49,
"text": "Alternative splicing of HSPA12A pre-RNA by SRSF11",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36394206",
"endSection": "title"
},
{
"offsetInBeginSection": 1600,
"offsetInEndSection": 1... |
63f03fc8f36125a426000021 | What disease can be treated with Lenacapavir? | Lenacapavir is a long-acting, highly potent HIV-1 capsid (CA) inhibitor that is approved for treatment of HIV-1. | [
"36272024",
"34871187",
"36190128",
"36202818"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 91,
"text": "Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36190128",
"endSection": "title"
},
{
"offsetInBeginS... |
641365f6201352f04a00003a | Is Iron deficiency anemia a common complication of chronic kidney disease? | iron deficiency anemia is common in patients with chronic kidney disease (CKD). | [
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"2012667... | yesno | [
{
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"text": "Intravenous iron therapy is increasingly being used worldwide to treat anemia in chronic kidney disease and more recently iron deficiency in heart failure.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubm... |
6410ef9b201352f04a000031 | Can modulation of KCNQ1 splicing prevent arrhythmias? | Amiloride reduces arrhythmogenicity through the modulation of KCNQ1 splicing. Therefore, the modulation of KCNQ1 splicing may help prevent arrhythmias. | [
"23608591"
] | yesno | [
{
"offsetInBeginSection": 1547,
"offsetInEndSection": 1758,
"text": "Amiloride regulates IKs and APs with transmural differences and reduces arrhythmogenicity through the modulation of KCNQ1 splicing. We suggested that the modulation of KCNQ1 splicing may help prevent arrhythmia.",
"beginSection": "... |
63f57f7f33942b094c000006 | What is Catamenial pneumothorax? | Catamenial pneumothorax is defined as a recurrent, spontaneous pneumothorax occurring within a day before or 72 h after the onset of menstruation. It is a manifestation of a thoracic endometriosis syndrome. | [
"35286587",
"34375738",
"35774053",
"35924495",
"35268286",
"36179536",
"35037874"
] | summary | [
{
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"text": "Catamenial pneumothorax is one of the most frequent manifestation in terms of a thoracic endometriosis syndrome (TES).",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/35924495",
"endSection": "ab... |
64144419201352f04a000045 | Please summarize haptenization. | Haptenization is the reaction of an antigenic compound (a hapten) with a carrier protein in order to stimulate an immune response. | [
"27539547",
"22613852",
"23928507"
] | summary | [
{
"offsetInBeginSection": 0,
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"text": "In contrast to the traditional mechanism of drug action that relies on the reversible, noncovalent interaction of a ligand with its biological target, a targeted covalent inhibitor (TCI) is designed such that the initial, reversible associ... |
6414c124690f196b51000002 | Is trichotillomania encountered with equali frequency in males and females? | No, the disease affects mainly female patients. | [
"35118122"
] | yesno | [
{
"offsetInBeginSection": 150,
"offsetInEndSection": 337,
"text": "The disease affects mainly female patients, who often deny the habit, and it usually presents with a bizarre pattern nonscarring patchy alopecia with short hair and a negative pull test. ",
"beginSection": "abstract",
"document":... |
64041701201352f04a000017 | What is the triad of the Eagle-Barrett Syndrome? | Eagle-Barrett Syndrome (EBS) is a rare congenital condition characterized by the triad of absent or defective abdominal wall muscles, urinary tract abnormalities, and bilateral cryptorchidism. | [
"35526214",
"35429431",
"30560020",
"29174092"
] | list | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 192,
"text": "Eagle-Barrett Syndrome (EBS) is a rare congenital condition characterized by the triad of absent or defective abdominal wall muscles, urinary tract abnormalities, and bilateral cryptorchidism.",
"beginSection": "abstract",
"documen... |
640c85e9201352f04a000026 | What cells proliferate in Mantle Cell Lymphoma | Mantle cell lymphoma is a subtype of B-cell non-Hodgkin's lymphoma, where B-cells proliferate uncontrollably. | [
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"10463985",
"10942246",
"8649059",
"28203581",
"32774275",
"26604506"
] | factoid | [
{
"offsetInBeginSection": 0,
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"text": "Mantle cell lymphoma (MCL) is a relatively rare B-cell non-Hodgkin lymphoma, typically presenting with extensive lymphadenopathy,",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/32774275",
"endSect... |
6415bb3c690f196b5100000e | What is the estimated cost reduction when using telegenetics? | The estimated cost reduction by online counseling is about 10-12%. | [
"26785833"
] | factoid | [
{
"offsetInBeginSection": 1548,
"offsetInEndSection": 1644,
"text": "We estimated reduced time and costs by online counseling with about 8% and 10-12%, respectively.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26785833",
"endSection": "abstract"
}
] |
63f03ae6f36125a42600001d | What is the target of BI 1015550? | BI 1015550 is a preferential phosphodiesterase 4B inhibitor that is used for patients with idiopathic pulmonary fibrosis. | [
"35569036",
"35517783",
"36299369"
] | factoid | [
{
"offsetInBeginSection": 181,
"offsetInEndSection": 402,
"text": "METHODS: In this phase 2, double-blind, placebo-controlled trial, we investigated the efficacy and safety of BI 1015550, an oral preferential inhibitor of the PDE4B subtype, in patients with idiopathic pulmonary fibrosis.",
"beginSec... |
64089be7201352f04a000022 | Please summarize the difference between REMS and RMPs | Risk Evaluation and Mitigation Strategies (REMS) are FDA-mandated programs that require drug manufacturers to develop and implement plans to ensure that the benefits of a drug outweigh its risks. Risk Management Plans (RMPs) are similar to REMS, but are used in the European Union and are focused on the safety of the patient. RMPs are designed to identify, characterize, and prevent or minimize risks associated with a drug. | [
"23244814"
] | summary | [
{
"offsetInBeginSection": 1496,
"offsetInEndSection": 1750,
"text": "Both REMS and RMPs provide positive guidance for identification, monitoring, and minimization of risk to patient safety. Currently, neither agency provides specific guidance on how risk should be related to benefit either qualitatively... |
63f9cd2f33942b094c000011 | Does microexon alternative splicing of small GTPase regulators have implication in central nervous system diseases? | Yes, microexon mis-splicing leads to dysregulation of the Rho GTPase pathway with implications in central nervous system diseases. | [
"34155820"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 106,
"text": "Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/34155820",
"endSection": "title"
},
{
... |
63eeeaaaf36125a426000004 | Beremagene Geperpavec is tested for which disease? | Beremagene Geperpavec was tested for recessive dystrophic epidermolysis bullosa. | [
"35347281"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 393,
"text": "Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis associated with blistering, wounding, and scarring caused by mutations in COL7A1, the gene encoding the anchoring fibril component, collagen VII (C7). Here, we ... |
64138ce8201352f04a000042 | Hairpatches is a single gene mutation associated with what disease? | Hairpatches is a single gene mutation associated with progressive renal failure and alopecia in mice, and may be a potential model for a newly described heritable human disorder. | [
"23301070",
"1836514"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 212,
"text": "\"Hairpatches\" (Hpt) is a naturally occurring, autosomal semi-dominant mouse mutation. Hpt/Hpt homozygotes die in utero, while Hpt/+ heterozygotes exhibit progressive renal failure accompanied by patchy alopecia. ",
"beginSection": "a... |
63f9cd0b33942b094c000010 | What is the alternative microexon splicing by RBFOX2 and PTBP1 associated with? | Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer | [
"36394206",
"34346508"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 107,
"text": "Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36394206",
"endSection": "title"
},
{
... |
63f56f7533942b094c000002 | Which gene is implicated in Canavan disease? | Canavan disease is an inherited leukodystrophy resulting from mutations in the gene encoding aspartoacylase (ASPA). | [
"36267868",
"35636725",
"35637731",
"35929936"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 102,
"text": "Cribriform Appearance of White Matter in Canavan Disease Associated with Novel Mutations of ASPA Gene.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36267868",
"endSection": "title"
},
{
"of... |
6411b4a8201352f04a000035 | Is prosopagnosia also known as lack of auditory recognition? | Prosopagnosia is a visual agnosia characterized by an inability to recognize previously known human faces and to learn new faces | [
"28539812",
"20850465",
"17186317",
"29213721",
"2697897",
"17981784",
"2684250",
"1796436",
"20182942",
"15098192",
"30625291",
"26321070",
"29213598",
"17402670",
"33184411",
"16767465"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 128,
"text": "Prosopagnosia is a visual agnosia characterized by an inability to recognize previously known human faces and to learn new faces",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/29213721",
"endSecti... |
6415babe690f196b5100000d | What is telegenetics? | Telegenetics involves the use of technology (generally video conferencing) to remotely provide genetic services. A telegenetics platform is critical for those with limitations or vulnerabilities compromising their ability to attend clinic in-person, including individuals in rural areas | [
"33817891"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 287,
"text": "Telegenetics involves the use of technology (generally video conferencing) to remotely provide genetic services. A telegenetics platform is critical for those with limitations or vulnerabilities compromising their ability to attend clinic ... |
63f04546f36125a426000024 | What is the mechanism of action of Mitapivat? | Mitapivat, an oral activator of pyruvate kinase in red blood cells, has shown significant improvements in haemoglobin and haemolysis among patients with pyruvate kinase deficiency who were not receiving regular transfusions. | [
"35576529",
"35964609",
"35988546"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 107,
"text": "A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/35576529",
"endSection": "title"
},
{
... |
641357bc201352f04a000039 | Do cells undergoing necroptosis show disruption of their cell membranes? | Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes | [
"33848465",
"27158445",
"31138766",
"35365636",
"30709919",
"28388412",
"30148498",
"31766571",
"30344099",
"32839552",
"31490656",
"29076500",
"28388403",
"30341907"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 314,
"text": "Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after its activation by the upstream kinases, receptor interacting... |
6414c3f3690f196b51000005 | What is the definition of dermatillomania? | Dermatillomania is a condition that leads to repetitive picking of their skin ending up in skin and soft tissue damage. It is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual's health and quality of life. | [
"33808008",
"21323095",
"33654612"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 241,
"text": "Dermatillomania or skin picking disorder (SPD) is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual's health and quality of life... |
63eeeb70f36125a426000005 | What disease can be treated with Glofitamab? | Glofitamab is being tested for treatment of DLBCL after CAR T-Cell Therapy | [
"35626120",
"34941996",
"36198538"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 78,
"text": "Glofitamab Treatment in Relapsed or Refractory DLBCL after CAR T-Cell Therapy.",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/35626120",
"endSection": "title"
},
{
"offsetInBeginSection": 361,... |
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