Interleukin-1 receptor antagonist protein
negative regulation of interleukin-1-mediated signaling pathway
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.