MHC class I polypeptide-related sequence B
response to oxidative stress
Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2).
The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR.