11-beta-hydroxysteroid dehydrogenase 1
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.