Let $F(x)$ be a polynomial such that $F(6) = 15$ and\[\frac{F(3x)}{F(x+3)} = 9-\frac{48x+54}{x^2+5x+6}\]for $x \in \mathbb{R}$ such that both sides are defined. Find $F(12)$.

Let's think step by step and output the final answer within \boxed{}.
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