Luke and Kate are co-workers at a Chicago brewery, where they spend their days drinking and flirting. They're perfect for each other, except that they're both in relationships. Luke is in the midst of marriage talks with his girlfriend of six years, Kate is playing it cool with her music producer boyfriend Chris. But you know what makes the line between "friends" and "more than friends" really blurry? Beer.

In Chicago, Kate is the PR of a brewery. Her boyfriend is Chris and her best friend is her coworker Luke, who lives with his girlfriend Jill. When Chris invites Luke and Jill to spend the weekend at his house by the lake, he gets closer to Jill while Kate spends most of the time with Luke. When they return to the city, Chris breaks up with Kate. She becomes upset and decides to celebrate with her coworkers in a bar; then she has one night stand with her colleague Dave. When Luke learns what happened in the previous night, he becomes kind of jealous. Will their relationship be affected?