tl;dr: Who (or what) a person in Runeterra prays to depends entirely on who they are and where they are.

Runeterra is as complex and diverse as our own world, with a myriad of faiths, religions and philosophies. Unlike our world, there are no individual organized religions which dominate globally. Our world building team has been working on the various factions and civilizations that can be found in Runeterra, and this has included exploring the cosmology and religions of those factions. As we publish more lore and storytelling (like our comics), we’ will continue to explore these factions and their individual characteristics, including things such as philosophy and religion.

The challenge is that Religions, at a fundamental level, developed in an entirely different way on Runeterra. Imagine a place in which the classical questions of our world, —does god(s) exist? What does god(s) want? Is there an afterlife?— are entirely redundant. In Runeterra, the presence of higher powers is indisputable and can be witnessed. Individuals with god -like powers walk through the world, and, the effects of magic and celestial power can be seen in the very landscape. From the celestial gate way on top of Mount Targon, through the vast sun disk in Shurima, to the void- scarred wastes of Icathia…

In such a world, religions are much more focused on understanding the will and intent of these powers, divining and communicating with them, worshipping them, and adhering to whatever covenant that power demands. The complexity comes from the blurred lines between gods (as we would understand them) and powerful beings who possess extraordinary powers but not the limitless command of the forces of the universe. In one sense, at least at a local level, it’s probably best to worship the being or celestial entity who is literally present. Make offerings, gain their favor, make requests of them. In other cases, you may want to seek a higher and greater power to save you from those same beings.

Like Ancient Greece, the issue is not believing in Gods, —it’s dealing with the wide variety and forms of them, figuring out which of them are benevolent or malicious, and navigating the complex hierarchy of heroes, demigods, titans and deities.

What is certainly universal to all religions in Runeterra is that while the hand of a supreme power can be seen in the presence of things like magic, celestial beings and champions, the highest level of cosmic creator is still a philosophical mystery. As indeed is what lies beyond in the afterlife.