"Berzerk" sold 362,000 downloads in its first week in the US, debuting at number three on the Billboard Hot 100 becoming Eminem's 15th Top 10 hit on the Hot 100.[15] The song has peaked at number two on the Hot R&B/Hip-Hop Songs chart.[16] When the R&B component of the chart is removed, the song debuted at number one on the Rap Songs chart.[15] "Berzerk"'s debut is just below the debut of the lead single for Recovery, "Not Afraid", which sold 379,000 copies in its first week.[17] It has sold over a million copies in the US as of October 2013.[18]

In Canada, the song debuted at number two with 50,000 downloads sold, which more than doubled the 24,000 downloads sold in the debut week of "Not Afraid".[19] It was Eminem's best one week download total ever in the country, until it was surpassed by the 54,000 downloads sold for Eminem's later single, "The Monster".[20] The song was certified Double Platinum in Digital downloads in Canada on November 1, 2013.[21]

The song debuted at number one on the UK R&B Chart[22] and was replaced on the chart by his single "Rap God".[23]