Bill Clinton ended his role with a for-profit college system on Friday, nearly two weeks after his wife, Hillary Rodham Clinton, began her second presidential campaign and singled out that industry for criticism.

Mr. Clinton’s role as honorary chancellor for the college system, Laureate International Universities, was part of a five-year deal that began on April 24, 2010, an aide with his office said. The end of the agreement was first reported by Bloomberg Politics, and an aide to Mr. Clinton told Bloomberg that the separation had nothing to do with Mrs. Clinton’s campaign.

“Laureate students represent the next generation of leadership,” Mr. Clinton said in a statement posted on the Laureate website in which he announced his departure. “I have seen a commitment to quality and leadership throughout the Laureate network, and I have enjoyed being a part of it.”

The university system — part of Laureate Education Inc., which according to Bloomberg is the world’s largest for-profit college chain — has been a seven-figure donor to the Clinton Foundation, giving between $1 million and $5 million, according to the foundation’s website. Laureate has also made five commitments through the Clinton Global Initiative.