Donald Trump tore into Hillary Clinton in a major speech on Wednesday, characterizing her as a "self-serving" politician who's manipulated Americans for decades to maximize her power and benefit herself financially.

"Hillary Clinton has perfected the politics of personal profit and theft," the presumptive Republican presidential nominee said, speaking to a crowd at his SoHo hotel in New York City. "She ran the State Department like her own personal hedge fund – doing favors for oppressive regimes, and many others, in exchange for cash."

In short but stinging soundbites, Trump slammed Clinton's long-standing ties to special interest groups, chastised her record as secretary of state and claimed she is the personification of corruption in politics.

"She gets rich making you poor," he said, later adding that Clinton "may be the most corrupt person ever to seek the presidency."

Over the course of forty minutes, Trump broke down several of the scandals that have plagued Clinton's presidential bid, beginning with the unsecure email server she kept during her tenure at the State Department and ending with the Clinton Foundation's acceptance of million-dollar contributions from foreign governments with which the U.S. maintains complex relationships.

"Hillary Clinton's State Department approved the transfer of 2 percent of America's uranium holdings to Russia, while nine investors in the deal funneled $145 million to the Clinton Foundation," Trump charged.

"Hillary Clinton appointed a top donor to a national security board with top secret access – even though he had no national security credential," he said, describing her as a "world-class liar."

Trump drew heavily from two books – conservative author Peter Schweizer's "Clinton Cash: The Untold Story of How and Why Foreign Governments and Businesses Helped Make Bill and Hillary Rich" and former Secret Service agent Gary Byrnes' "Crisis in Character" – to level attacks against his Democratic opponent.

He contrasted Clinton's domestic and foreign policy prescriptions with his own, claiming she would emulate President Obama and advance his administration's efforts to grant reprieve to illegal immigrants, raise taxes on wealthier Americans and pursue what has been described as a "light footprint" strategy against radical Islamic extremism.

"The voters are the jury. Their ballots are the verdict. We don't need or want another Clinton or Obama," he said.

Winding down his prepared remarks, Trump encouraged Americans not to tolerate "politicians [who] have sacrificed their security, betrayed their prosperity and sold out their country."

"Hillary Clinton's message is old and tired. Her message is that things can't change," he said. "My message is that things have to change – and this is our one chance do it. This is our last chance to do it."

Wednesday marked the first Clinton-focused speech Trump has delivered since clinching the GOP nomination last month. After edging her in general election matchup polls for a short period in May, he now trails the former first lady by 5.8 percentage points in the RealClearPolitics polling average.