A bus and a car collided on Anzac Pde bridge, closing the road at the Memorial Dr end.

A man has died in a collision between a bus and car on one of Hamilton's central city bridges.

The 55-year-old driver of the silver vehicle died at the scene of the collision on the Anzac Pde bridge, despite frantic efforts to administer CPR.

Inside the car with him was a young girl.

PHILLIPA YALDEN/FAIRFAX NZ The scene a few minutes after the crash on the Victoria Bridge in Hamilton.

Police were now trying to get hold of the man's next of kin to inform them, Senior Sergeant Ray Malcolmson of Waikato police said.

It appeared the silver car was heading towards the city when it drifted into the path of an oncoming bus heading towards Hamilton East around 2.10pm on Saturday, he said.

There were no passengers onboard the bus at the time, he said, and the bus driver was uninjured.

Debris from the impact on the driver's side of the bus lay strewn across the intersection of Memorial Dr.

The silver hatchback came to rest about 15 metres onto the bridge from the Hamilton East side.

Anzac Parade, otherwise known as Victoria Bridge, was closed to all traffic following the crash.

Multiple police and ambulances were on scene.

Malcolmson said all traffic was being stopped at the intersection of Victoria St and Anzac Pde and at Memorial Drive entrance to Anzac Parade.

All motorists should use alternate routes, such as the Cobham Drive Bridge, Hamilton East or the Claudelands Drive Bridge, Hamilton Central for at least the next few hours.