A new episode of The Simpsons featuring New Zealand's Flight of the Conchords and the Wellington Botanic Gardens will air for the first time tonight.

The Simpsons begins its 22nd season on Fox Broadcasting in the US with an episode titled "Elementary School Musical".

The storyline has Marge Simpson sending Lisa to a performing arts camp where Jemaine Clement and Bret McKenzie of Flight of the Conchords become her counsellors.

In their typically bumbling way, the pair try to give Lisa and her fellow campers (including Glee stars Lea Michele, Cory Monteith and Amber Riley) acting advice.

In one part, Jemaine heckles the actors with the call: "I've seen more life in the Wellington Botanic Gardens," while Bret worries if the actors will understand the reference.

According to Fox, the camp helps Lisa "connect with her inner hipster."

"The Simpsons" is prime-time television's longest-running comedy, debuting in December 1989.

Other guest voices on The Simpsons this season will include Oscar winner Halle Berry, basketball legend Kareem Abdul-Jabbar, race car driver Danica Patrick and the comic duo Cheech & Chong.

Daniel Radcliffe from Harry Potter and Hugh Laurie from House will be guest voices on the Halloween episode, "Treehouse of Horror XXI."