Karl Rove's American Crossroads is spending $10,000 on an online ad taking aim at actress Ashley Judd's political views -- the latest sign that her possible challenge to Senate Minority Leader Mitch McConnell (R-Ky.) is one Republicans take seriously.

The ad, released Wednesday and called "Ashley's Story," highlights clips of the actress professing her support for Obama and his health care plan, and quotes a Daily Caller story where her grandmother called her a "Hollywood liberal."

It also hits Judd for saying, "Tennessee is home." While Judd grew up in Kentucky, she currently lives in Tennessee, and attended the DNC as a delegate for that state.

“Ashley Judd: An Obama-following radical Hollywood liberal, who’s right at home in Tennessee. I mean Kentucky,” the narrator of the ad intones.

The ad will run for two weeks in Kentucky, starting Wednesday, according to American Crossroads.

Watch the ad:

The video's lines of attack closely follow some of the talking points that McConnell's camp tested in a December poll, including her ties to Tennessee and the "Hollywood liberal" hit. Both McConnell's internal polling and a survey by the Democratic firm PPP showed the senator leading Judd by a 4-point margin.

Judd has expressed interest in the race, but hasn't announced whether she will run.