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Treatment for Type 1 Diabetes Mellitus: Membrane for Transplanted Langerhans Islet Cells

Although we all have been waiting for the resolution of type 1 diabetes mellitus for years, now we are individuals who have become accustomed to life with diabetes. Those of us who think that type 1 diabetes mellitus will be trapped in a membrane or capsule of stem cell transplants or langerhans islet cells and that the attack of the immune system will be prevented and terminated with insulin secretion, although we all have different opinions.

Type 1 Diabetes Insulin Treatment

By the way, the pancreas has about a mile of Langerhans Island. Islets include four distinct cell lines; the alpha, beta and delta cells produce hormones and the function of the fourth cell line (cells C) is unknown. That is, we are also suffering from the functioning of alpha (glucagon secretory) cells, while we are unable to function as insulin releasing beta cells in type 1 diabetics.

This work is a new addition to the University of Twente in the Netherlands. In this type of study of type 1 diabetes mellitus, the immune system is attacked and the langerhans islets to be transported, especially because the beta cells are killed by the hostile and immune system, must be protected. For this reason, a capsule, ring or membrane is produced. The principle of this membrane is also very interesting. Made semi-permeable, this membrane will be able to deliver glucose to target cells by beta cells.

Researcher Prof. Dimitrios Stamatialis emphasizes that this membrane containing langerhans islands needs a long time to be implanted into human beings and it is a promising work for the future. Now they will continue their animal experiments after they have done this in laboratory conditions.

Professor Dimitrios Stamatisis emphasizes that the creation of islets is possible with the use of stem cells, especially when the membrane is made of animal islets and is needed. For this reason, the xenotransplantation option is also important. In other words, it notes that there is a need for tissue and /or organ transplants carried out phylogenetically between different species.

This investigation; Twente University was undertaken by researchers at the MIRA Research Institute, Radboud University Medical Center, Leiden University Medical Center, Hubrecht Institute and Maastricht University.

Source: http://www.engineeringnet.nl/detail_nederland.asp?Id=19465&category=research&titel=Oplossing%20in%20zicht%20voor%20diabetes%20type%201%20patienten