Question: Recognizing daily routines by identifying specific activities.

This document outlines a novel methodology for swift visual object detection, achieving high detection rates while processing images at remarkable speeds. The proposed approach is characterized by three primary innovations. Firstly, it introduces the "Integral Image" representation, a technique that facilitates the swift computation of features utilized by the detector. Secondly, the learning algorithm employed is an adaptation of AdaBoost, which judiciously selects a subset of critical visual features from a larger pool, resulting in highly efficient classifiers. Thirdly, the system incorporates a cascading mechanism that combines increasingly complex classifiers, enabling the rapid exclusion of image areas unlikely to contain the object of interest, while directing more computational resources towards regions that resemble potential objects. This cascading structure acts as an object-specific focus-of-attention mechanism, offering statistical assurances that regions discarded early in the process are improbable to contain the target object. In the context of face detection, the system's performance matches that of the most advanced systems to date. Notably, the detector is capable of operating in real-time applications at a rate of 15 frames per second, without reliance on image differencing or skin color detection techniques.

**Question**: Impact of Social Media on Mental Health

**Documents**: The Effects of Social Media on College Students
Social media has transformed the way people communicate and socialize on the internet. With the increasing usage of digital technology, social media platforms such as Facebook, Twitter, Instagram, and Snapchat have become an integral part of daily life for many people, particularly college students. This study aims to explore the effects of social media on the mental health of college students. A survey was conducted among 300 college students to assess their social media usage patterns and mental health status. The results indicate that social media usage is significantly associated with symptoms of depression, anxiety, and stress. Students who spend more time on social media platforms are more likely to experience negative mental health outcomes. The study also found that social media can lead to feelings of isolation, loneliness, and low self-esteem, especially when students compare themselves to others online. However, social media can also have positive effects on mental health, such as providing support and reducing feelings of loneliness. The findings of this study suggest that social media usage should be monitored and moderated to prevent negative mental health outcomes among college students.

**Similar Documents**: This research investigates the influence of social media on the psychological well-being of college students, a demographic heavily engaged in digital platforms like Facebook, Twitter, Instagram, and Snapchat. The study, conducted among a cohort of 300 college students,

Intelligent agents, such as robots, have to serve a multitude of autonomous functions. Examples are, e.g., collision avoidance, navigation and route planning, active sensing of its environment, or the interaction and non-verbal communication with people in the extended reach space. Here, we focus on the recognition of the action of a human agent based on a biologically inspired visual architecture of analyzing articulated movements. The proposed processing architecture builds upon coarsely segregated streams of sensory processing along different pathways which separately process form and motion information (Layher et al., 2014). Action recognition is performed in an event-based scheme by identifying representations of characteristic pose configurations (key poses) in an image sequence. In line with perceptual studies, key poses are selected unsupervised utilizing a feature-driven criterion which combines extrema in the motion energy with the horizontal and the vertical extendedness of a body shape. Per class representations of key pose frames are learned using a deep convolutional neural network consisting of 15 convolutional layers. The network is trained using the energy-efficient deep neuromorphic networks (Eedn) framework (Esser et al., 2016), which realizes the mapping of the trained synaptic weights onto the IBM Neurosynaptic System platform (Merolla et al., 2014). After the mapping, the trained network achieves real-time capabilities for processing input streams and classify input images at about 1,000 frames per second while the computational stages only consume about 70 mW of energy (without spike transduction). Particularly regarding mobile robotic systems, a low energy profile might be crucial in a variety of application scenarios. Cross-validation results are reported for two different datasets and compared to state-of-the-art action recognition approaches. The results demonstrate, that (I) the presented approach is on par with other key pose based methods described in the literature, which select key pose frames by optimizing classification accuracy, (II) compared to the training on the full set of frames, representations trained on key pose frames result in a higher confidence in class assignments, and (III) key pose representations show promising generalization capabilities in a cross-dataset evaluation.

Activity tracking using a wearable device is an emerging research field. Large-scale studies on activity tracking performed with eyewear-type wearable devices remains a challenging area owing to the negative effect such devices have on users' looks. To cope with this challenge, JINS Inc., an eyewear retailer in Japan, has developed a state-of-the-art smart eyewear called JINS MEME. The design of JINS MEME is almost the same as that of Wellington-type eyeglasses so that people can use it in their daily lives. JINS MEME is equipped with sensors to detect a user's eye movement and head motion. In addition to these functions of JINS MEME, JINS developed an application to measure concentration levels of users. In this demonstration, users will experience wearing the JINS MEME glasses and their concentration will be measured while they perform a certain task at our booth.

Awareness of the emotion of those who communicate with others is a fundamental challenge in building affective intelligent systems. Emotion is a complex state of the mind influenced by external events, physiological changes, or relationships with others. Because emotions can represent a user's internal context or intention, researchers suggested various methods to measure the user's emotions from analysis of physiological signals, facial expressions, or voice. However, existing methods have practical limitations to be used with consumer devices, such as smartphones; they may cause inconvenience to users and require special equipment such as a skin conductance sensor. Our approach is to recognize emotions of the user by inconspicuously collecting and analyzing user-generated data from different types of sensors on the smartphone. To achieve this, we adopted a machine learning approach to gather, analyze and classify device usage patterns, and developed a social network service client for Android smartphones which unobtrusively find various behavioral patterns and the current context of users. Also, we conducted a pilot study to gather real-world data which imply various behaviors and situations of a participant in her/his everyday life. From these data, we extracted 10 features and applied them to build a Bayesian Network classifier for emotion recognition. Experimental results show that our system can classify user emotions into 7 classes such as happiness, surprise, anger, disgust, sadness, fear, and neutral with a surprisingly high accuracy. The proposed system applied to a smartphone demonstrated the feasibility of an unobtrusive emotion recognition approach and a user scenario for emotion-oriented social communication between users.

Wayfinding is a basic activity people do throughout their entire lives as they navigate from one place to another. In order to create different spaces in such a way that they facilit ate people’s wayfinding it is necessary to integrate principles of human spatial cognition into the design process. This paper presents a methodology to structure space based on experiental patterns, called image schemata. It integrates cognitive and engineering aspects in three steps: (1) interviewing people about their spatial experiences as they perform a wayfinding task in the application space, (2) extracting the image schemata from these interviews and formulating a sequence of subtasks, and (3) structuring the application space (i.e., the wayfinding task) with the extracted image schemata. We use wayfinding in airports as a case study to demonstrate the methodology. Our observations show that most often image schemata are correlated with other image schemata in the form of image-schematic blocks and rarely occur in isolation. Such image-schematic blocks serve as a knowledge-representation scheme for wayfinding tasks.

The visual recognition of complex, articulated human movements is fundamental for a wide range of artificial systems oriented toward human-robot communication, action classification, and action-driven perception. These challenging tasks may generally involve the processing of a huge amount of visual information and learning-based mechanisms for generalizing a set of training actions and classifying new samples. To operate in natural environments, a crucial property is the efficient and robust recognition of actions, also under noisy conditions caused by, for instance, systematic sensor errors and temporarily occluded persons. Studies of the mammalian visual system and its outperforming ability to process biological motion information suggest separate neural pathways for the distinct processing of pose and motion features at multiple levels and the subsequent integration of these visual cues for action perception. We present a neurobiologically-motivated approach to achieve noise-tolerant action recognition in real time. Our model consists of self-organizing Growing When Required (GWR) networks that obtain progressively generalized representations of sensory inputs and learn inherent spatio-temporal dependencies. During the training, the GWR networks dynamically change their topological structure to better match the input space. We first extract pose and motion features from video sequences and then cluster actions in terms of prototypical pose-motion trajectories. Multi-cue trajectories from matching action frames are subsequently combined to provide action dynamics in the joint feature space. Reported experiments show that our approach outperforms previous results on a dataset of full-body actions captured with a depth sensor, and ranks among the best results for a public benchmark of domestic daily actions.

While indoor portable navigation using portable devices is becoming increasingly required, it faces many challenges in obtaining accurate positioning performance. One of the methods to improve navigation results is to recognize the mode of motion of the user carrying the portable device containing low-cost microelectromechanical systems (MEMS) motion sensors. Pattern recognition methodology has been employed to detect a group of motion modes that are common indoors, namely, walking, stationary, going up/down stairs, standing on an escalator, walking on an escalator, standing on a moving walkway, and walking on a moving walkway. The performance of the motion mode recognition module was examined on different types of mobile computing devices, including various brands of smartphones, tablets, smartwatches, and smartglasses, and the results obtained showed the capability of enhancing positioning performance. The module does not require satellite or wireless positioning signals, and depends only on MEMS sensors.

Group activity recognition plays a fundamental role in a variety of applications, e.g. sports video analysis and intelligent surveillance. How to model the spatio-temporal contextual information in a scene still remains a crucial yet challenging issue. We propose a novel attentive semantic recurrent neural network (RNN), dubbed as stagNet, for understanding group activities in videos, based on the spatio-temporal attention and semantic graph. A semantic graph is explicitly modeled to describe the spatial context of the whole scene, which is further integrated with the temporal factor via structural-RNN. Benefiting from the ‘factor sharing’ and ‘message passing’ mechanisms, our model is capable of extracting discriminative spatio-temporal features and capturing inter-group relationships. Moreover, we adopt a spatio-temporal attention model to attend to key persons/frames for improved performance. Two widely-used datasets are employed for performance evaluation, and the extensive results demonstrate the superiority of our method.

We live life in the network. We check our e-mails regularly, make mobile phone calls from almost any location ... make purchases with credit cards ... [and] maintain friendships through online social networks. ... These transactions leave digital traces that can be compiled into comprehensive pictures of both individual and group behavior, with the potential to transform our understanding of our lives, organizations, and societies.

This paper presents ElectriSense, a new solution for automatically detecting and classifying the use of electronic devices in a home from a single point of sensing. ElectriSense relies on the fact that most modern consumer electronics and fluorescent lighting employ switch mode power supplies (SMPS) to achieve high efficiency. These power supplies continuously generate high frequency electromagnetic interference (EMI) during operation that propagates throughout a home's power wiring. We show both analytically and by in-home experimentation that EMI signals are stable and predictable based on the device's switching frequency characteristics. Unlike past transient noise-based solutions, this new approach provides the ability for EMI signatures to be applicable across homes while still being able to differentiate between similar devices in a home. We have evaluated our solution in seven homes, including one six-month deployment. Our results show that ElectriSense can identify and classify the usage of individual devices with a mean accuracy of 93.82%.

Learning and then recognizing a route, whether travelled during the day or at night, in clear or inclement weather, and in summer or winter is a challenging task for state of the art algorithms in computer vision and robotics. In this paper, we present a new approach to visual navigation under changing conditions dubbed SeqSLAM. Instead of calculating the single location most likely given a current image, our approach calculates the best candidate matching location within every local navigation sequence. Localization is then achieved by recognizing coherent sequences of these “local best matches”. This approach removes the need for global matching performance by the vision front-end - instead it must only pick the best match within any short sequence of images. The approach is applicable over environment changes that render traditional feature-based techniques ineffective. Using two car-mounted camera datasets we demonstrate the effectiveness of the algorithm and compare it to one of the most successful feature-based SLAM algorithms, FAB-MAP. The perceptual change in the datasets is extreme; repeated traverses through environments during the day and then in the middle of the night, at times separated by months or years and in opposite seasons, and in clear weather and extremely heavy rain. While the feature-based method fails, the sequence-based algorithm is able to match trajectory segments at 100% precision with recall rates of up to 60%.


Question: Recognizing daily routines by identifying specific activities.

This paper delves into the statistical underpinnings of boosting, a powerful technique in classification methodology that has gained significant attention for its ability to enhance classifier performance. Boosting operates by repeatedly applying a classification algorithm to reweighted versions of the training data, culminating in a weighted majority vote of the classifiers produced in this iterative process. This method often leads to substantial improvements in classification accuracy for various algorithms. We elucidate this phenomenon by drawing parallels with established statistical concepts, specifically additive modeling and maximum likelihood estimation. For binary classification problems, boosting can be interpreted as an approximation to additive modeling on the logistic scale, using maximum Bernoulli likelihood as the optimization criterion. We propose more direct approximations and demonstrate that they yield outcomes similar to those achieved by boosting. We further extend this framework to multiclass classification, deriving generalizations based on multinomial likelihood that match or outperform other recent multiclass boosting approaches in certain scenarios. To streamline computation, we suggest a minor modification to the boosting algorithm, which can result in notable time savings, often by factors of 10 to 50. Lastly, we introduce an alternative formulation of boosting for decision tree induction. This approach, which leverages best-first truncated tree induction, not only frequently outperforms conventional boosting but also offers more interpretable aggregate decision rules and is significantly faster, making it particularly well-suited for large-scale data mining applications.

Mobile devices provide a continuous data stream of contextual behavioral information which can be leveraged for a variety of user services, such as in personalizing ads and customizing home screens. In this paper, we aim to better understand gender-related behavioral patterns found in application, Bluetooth, and Wi-Fi usage. Using a dataset which consists of approximately 19 months of data collected from 189 subjects, gender classification is performed using 1,000 features related to the frequency of events yielding up to 91.8% accuracy. Then, we present a behavioral analysis of application traffic using techniques commonly used for web browsing activity as an alternative data exploration approach. Finally, we conclude with a discussion on impersonation attacks, where we aim to determine if one gender is less vulnerable to unauthorized access on their mobile device.

Recognizing high-level human behavior and decisions from their digital traces are critical issues in pervasive computing systems. In this paper, we develop a novel methodology to reveal cabdrivers’ operation patterns by analyzing their continuous digital traces. For the first time, we systematically study large scale cabdrivers’ behavior in a real and complex city context through their daily digital traces. We identify a set of valuable features, which are simple and effective to classify cabdrivers, delineate cabdrivers’ operation patterns and compare the different cabdrivers’ behavior. The methodology and steps could spatially and temporally quantify, visualize, and examine different cabdrivers’ operation patterns. Drivers were categorized into top drivers and ordinary drivers by their daily income. We use the daily operations of 3000 cabdrivers in over 48 million of trips and 240 million kilometers to uncover: (1) spatial selection behavior, (2) context-aware spatio-temporal operation behavior, (3) route choice behavior, and (4) operation tactics. Though we focused on cabdriver operation patterns analysis from their digital traces, the methodology is a general empirical and analytical methodology for any GPS-like trace analysis. Our work demonstrates the great potential to utilize the massive pervasive data sets to understand human behavior and high-level intelligence. Published by Elsevier Ltd.

How do humans recognize the action “opening a book”? We argue that there are two important cues: modeling temporal shape dynamics and modeling functional relationships between humans and objects. In this paper, we propose to represent videos as space-time region graphs which capture these two important cues. Our graph nodes are defined by the object region proposals from different frames in a long range video. These nodes are connected by two types of relations: (i) similarity relations capturing the long range dependencies between correlated objects and (ii) spatial-temporal relations capturing the interactions between nearby objects. We perform reasoning on this graph representation via Graph Convolutional Networks. We achieve state-of-the-art results on both Charades and Something-Something datasets. Especially for Charades, we obtain a huge 4.4% gain when our model is applied in complex environments.

The aim of this paper is to address recognition of natural human actions in diverse and realistic video settings. This challenging but important subject has mostly been ignored in the past due to several problems one of which is the lack of realistic and annotated video datasets. Our first contribution is to address this limitation and to investigate the use of movie scripts for automatic annotation of human actions in videos. We evaluate alternative methods for action retrieval from scripts and show benefits of a text-based classifier. Using the retrieved action samples for visual learning, we next turn to the problem of action classification in video. We present a new method for video classification that builds upon and extends several recent ideas including local space-time features, space-time pyramids and multi-channel non-linear SVMs. The method is shown to improve state-of-the-art results on the standard KTH action dataset by achieving 91.8% accuracy. Given the inherent problem of noisy labels in automatic annotation, we particularly investigate and show high tolerance of our method to annotation errors in the training set. We finally apply the method to learning and classifying challenging action classes in movies and show promising results.

Representing and summarizing human behaviors with rich contexts facilitates behavioral sciences and user-oriented services. Traditional behavioral modeling represents a behavior as a tuple in which each element is one contextual factor of one type, and the tensor-based summaries look for high-order dense blocks by clustering the values (including timestamps) in each dimension. However, the human behaviors are multicontextual and dynamic: (1) each behavior takes place within multiple contexts in a few dimensions, which requires the representation to enable non-value and set-values for each dimension; (2) many behavior collections, such as tweets or papers, evolve over time. In this paper, we represent the behavioral data as a two-level matrix (temporal-behaviors by dimensional-values) and propose a novel representation for behavioral summary called Tartan that includes a set of dimensions, the values in each dimension, a list of consecutive time slices and the behaviors in each slice. We further develop a propagation method CatchTartan to catch the dynamic multicontextual patterns from the temporal multidimensional data in a principled and scalable way: it determines the meaningfulness of updating every element in the Tartan by minimizing the encoding cost in a compression manner. CatchTartan outperforms the baselines on both the accuracy and speed. We apply CatchTartan to four Twitter datasets up to 10 million tweets and the DBLP data, providing comprehensive summaries for the events, human life and scientific development.

We live life in the network. We check our e-mails regularly, make mobile phone calls from almost any location ... make purchases with credit cards ... [and] maintain friendships through online social networks. ... These transactions leave digital traces that can be compiled into comprehensive pictures of both individual and group behavior, with the potential to transform our understanding of our lives, organizations, and societies.

We present a review on the current state of publicly available datasets within the human action recognition community; highlighting the revival of pose based methods and recent progress of understanding person-person interaction modeling. We categorize datasets regarding several key properties for usage as a benchmark dataset; including the number of class labels, ground truths provided, and application domain they occupy. We also consider the level of abstraction of each dataset; grouping those that present actions, interactions and higher level semantic activities. The survey identifies key appearance and pose based datasets, noting a tendency for simplistic, emphasized, or scripted action classes that are often readily definable by a stable collection of subaction gestures. There is a clear lack of datasets that provide closely related actions, those that are not implicitly identified via a series of poses and gestures, but rather a dynamic set of interactions. We therefore propose a novel dataset that represents complex conversational interactions between two individuals via 3D pose. 8 pairwise interactions describing 7 separate conversation based scenarios were collected using two Kinect depth sensors. The intention is to provide events that are constructed from numerous primitive actions, interactions and motions, over a period of time; providing a set of subtle action classes that are more representative of the real world, and a challenge to currently developed recognition methodologies. We believe this is among one of the first datasets devoted to conversational interaction classification using 3D pose Preprint submitted to Elsevier October 27, 2015 features and the attributed papers show this task is indeed possible. The full dataset is made publicly available to the research community at [1].

Context-awareness can improve the usefulness of automated reminders. However, context-aware reminder applications have yet to be evaluated throughout a person’s daily life. Mobile phones provide a potentially convenient and truly ubiquitous platform for the detection of personal context such as location, as well as the delivery of reminders. We designed Place-Its, a location-based reminder application that runs on mobile phones, to study people using location-aware reminders throughout their daily lives. We describe the design of Place-Its and a two-week exploratory user study. The study reveals that location-based reminders are useful, in large part because people use location in

A datatype with increasing importance in GIS is what we call the location history–a record of an entity’s location in geographical space over an interval of time. This paper proposes a number of rigorously defined data structures and algorithms for analyzing and generating location histories. Stays are instances where a subject has spent some time at a single location, and destinations are clusters of stays. Using stays and destinations, we then propose two methods for modeling location histories probabilistically. Experiments show the value of these data structures, as well as the possible applications of probabilistic models of location histories.

OBJECTIVE
In this paper we propose artificial intelligence methods to estimate cardiorespiratory fitness (CRF) in free-living using wearable sensor data.

METHODS
Our methods rely on a computational framework able to contextualize heart rate (HR) in free-living, and use context-specific HR as predictor of CRF without need for laboratory tests. In particular, we propose three estimation steps. Initially, we recognize activity primitives using accelerometer and location data. Using topic models, we group activity primitives and derive activities composites. We subsequently rank activity composites, and analyze the relation between ranked activity composites and CRF across individuals. Finally, HR data in specific activity primitives and composites is used as predictor in a hierarchical Bayesian regression model to estimate CRF level from the participant's habitual behavior in free-living.

RESULTS
We show that by combining activity primitives and activity composites the proposed framework can adapt to the user and context, and outperforms other CRF estimation models, reducing estimation error between 10.3% and 22.6% on a study population of 46 participants.

CONCLUSIONS
Our investigation showed that HR can be contextualized in free-living using activity primitives and activity composites and robust CRF estimation in free-living is feasible.


Question: Recognition of daily routines through the identification of specific activities.

This paper explores a novel strategy for optimizing the detection of numerous object classes within cluttered visual scenes, aiming to enhance efficiency and reduce the training data requirements. Conventional methods typically involve applying a series of distinct classifiers to an image across various locations and scales, a process that can be computationally intensive and resource-hungry, as each classifier necessitates the calculation of a multitude of image features. Notably, when object detectors are trained independently, both the computational complexity at runtime and the sample complexity during training scale linearly with the number of classes to be identified. To address these limitations, we propose a multitask learning framework based on boosted decision stumps. This approach significantly mitigates computational and sample complexity by identifying and leveraging shared visual features that are applicable across different object classes (and/or perspectives). Instead of training each class's detector in isolation, our method facilitates joint training, which has been shown to substantially decrease the total number of features required, and thus the runtime costs of the classifier, scaling approximately logarithmically with the number of classes. The features selected through joint training are characterized as generic, edge-like patterns, in contrast to the more specific object-oriented features chosen by independent class training. These generic features exhibit superior generalization capabilities and markedly lower computational overhead, making them highly effective for multiclass object detection tasks.

People spend most of their time at a few key locations, such as home and work. Being able to identify how the movements of people cluster around these “important places” is crucial for a range of technology and policy decisions in areas such as telecommunications and transportation infrastructure deployment. In this paper, we propose new techniques based on clustering and regression for analyzing anonymized cellular network data to identify generally important locations, and to discern semantically meaningful locations such as home and work. Starting with temporally sparse and spatially coarse location information, we propose a new algorithm to identify important locations. We test this algorithm on arbitrary cellphone users, including those with low call rates, and find that we are within 3 miles of ground truth for 88% of volunteer users. Further, after locating home and work, we achieve commute distance estimates that are within 1 mile of equivalent estimates derived from government census data. Finally, we perform carbon footprint analyses on hundreds of thousands of anonymous users as an example of how our data and algorithms can form an accurate and efficient underpinning for policy and infrastructure studies.

In this paper, we propose an acceleration-based human activity recognition method using popular deep architecture, Convolution Neural Network (CNN). In particular, we construct a CNN model and modify the convolution kernel to adapt the characteristics of tri-axial acceleration signals. Also, for comparison, we use some widely used methods to accomplish the recognition task on the same dataset. The large dataset we constructed consists of 31688 samples from eight typical activities. The experiment results show that the CNN works well, which can reach an average accuracy of 93.8% without any feature extraction methods.

In this paper, a new approach in human identification is investigated. For this purpose, a standard 12-lead electrocardiogram (ECG) recorded during rest is used. Selected features extracted from the ECG are used to identify a person in a predetermined group. Multivariate analysis is used for the identification task. Experiments show that it is possible to identify a person by features extracted from one lead only. Hence, only three electrodes have to be attached on the person to be identified. This makes the method applicable without too much effort.

Digital reminder systems typically use time and place as triggers to remind people to perform activities. In this paper, we investigate how digital reminder systems could better support the process of remembering in a wider range of situations. We report findings from a survey and one-week diary study, which reveal that people want to remember to perform a broad spectrum of activities in the future, many of which cannot be supported by simple time- and location-based reminders. In addition to these examples of prospective memory, or ‘remembering intentions’ [53], we also find that people want support in ‘retrieving’ [53] information and details, especially those encountered through social interactions or intended for use in conversations with others. Drawing on our analysis of what people want to remember and how they try to support this, we draw implications for the design of intelligent reminder systems such as digital assistants (e.g. Microsoft’s Cortana) and smart speaker systems (e.g. Amazon Echo), and highlight the possibilities afforded by drawing on conversation and giving material form to digital reminders.

Recently, Wi-Fi has caught tremendous attention for its ubiquity. Motivated by Wi-Fi’s low cost and privacy preservation, researchers have been putting lots of investigation into its potential on action recognition and even person identification. In this paper, for bringing a new modality for multimedia community, we offer an comprehensive overview on these two topics in Wi-Fi. Also, through looking at these two topics from an unprecedented perspective, we could achieve generality instead of designing specific ad-hoc features for each scenario. Observing the great resemblance of Channel State Information (CSI, a finegrained information captured from the received Wi-Fi signal) to texture, we propose a brand-new framework based on computer vision methods. To minimize the effect of location dependency embedded in CSI, we propose a novel de-noising method based on Singular Value Decomposition (SVD) to eliminate the background energy and effectively extract the channel information of signals reflected by human bodies. From the experiments conducted, we demonstrate the feasibility and efficacy of the proposed methods. Also, we conclude the factors that would affect the performance and highlight a few potential issues that require further deliberations.

A novel system for the location of people in an office environment is described. Members of staff wear badges that transmit signals providing information about their location to a centralized location service, through a network of sensors. The paper also examines alternative location techniques, system design issues and applications, particularly relating to telephone call routing. Location systems raise concerns about the privacy of an individual and these issues are also addressed.

This paper presents an approach to people identification using gait based on floor pressure data. By using a large area high resolution pressure sensing floor, we were able to obtain 3D trajectories of the center of foot pressures over a footstep which contain both the 1D pressure profile and 2D position trajectories of the COP. Based on the 3D COP trajectories a set of features are then extracted and used for people identification together with other features such as stride length and cadence. The Fisher linear discriminant is used as the classifier. Encouraging results have been obtained using the proposed method with an average recognition rate of 94% and false alarm rate of 3% using pair-wise footstep data from 10 subjects.

Many practical tasks require accessing specific types of information in scientific literature; e.g. information about the objective, methods, results or conclusions of the study in question. Several schemes have been developed to characterize such information in full journal papers. Yet many tasks focus on abstracts instead. We take three schemes of different type and granularity (those based on section names, argumentative zones and conceptual structure of documents) and investigate their applicability to biomedical abstracts. We show that even for the finest-grained of these schemes, the majority of categories appear in abstracts and can be identified relatively reliably using machine learning. We discuss the impact of our results and the need for subsequent task-based evaluation of the schemes.

The recent introduction of robots to everyday scenarios has revealed new opportunities for collaboration and social interaction between robots and people. However, high level interaction will require semantic understanding of the environment. In this paper, we advocate that co-existence of assistive robots and humans can be leveraged to enhance the semantic understanding of the shared environment, and improve situation awareness. We propose a probabilistic framework that combines human activity sensor data generated by smart wearables with low level localisation data generated by robots. Based on this low level information and leveraging colocation events between a user and a robot, it can reason about semantic information and track humans and robots across different rooms. The proposed system relies on two-way sharing of information between the robot and the user. In the first phase, user activities indicative of room utility are inferred from consumer wearable devices and shared with the robot, enabling it to gradually build a semantic map of the environment. This will enable natural language interaction and high-level tasks for both assistive and co-working robots. In a second phase, via colocation events, the robot is able to share semantic information with the user, by labelling raw user data with semantic information about room type. Over time, the labelled data is used for training an Hidden Markov Model for room-level localisation, effectively making the user independent from the robot.

Context-awareness can improve the usefulness of automated reminders. However, context-aware reminder applications have yet to be evaluated throughout a person’s daily life. Mobile phones provide a potentially convenient and truly ubiquitous platform for the detection of personal context such as location, as well as the delivery of reminders. We designed Place-Its, a location-based reminder application that runs on mobile phones, to study people using location-aware reminders throughout their daily lives. We describe the design of Place-Its and a two-week exploratory user study. The study reveals that location-based reminders are useful, in large part because people use location in


Question: Recognition of daily routines through the identification of specific activities.

This paper introduces a novel method for recognizing human activities through a hybrid approach that merges discriminative and generative modeling techniques. The objective of accurately identifying and monitoring human activities is a critical aspect of ubiquitous computing. With the recent advancements in multi-modal wearable sensors, we now have the capability to amass extensive datasets capturing various human activities. Yet, the challenge of automatically selecting the most relevant features for activity modeling remains largely unresolved. Our proposed solution combines boosting techniques for the discriminative selection of useful features and the learning of an ensemble of static classifiers to recognize distinct activities, alongside hidden Markov models (HMMs) to encapsulate the temporal patterns and smooth transitions characteristic of human activities. To evaluate the efficacy of our activity recognition system, we conducted extensive testing using over 12 hours of data gathered from wearable sensors worn by volunteers in their natural, unrestricted environments. The results were promising; the models were successful in pinpointing a concise set of maximally informative features and achieved an accuracy rate of 95% in distinguishing between ten different human activities.

Recent advances in small inexpensive sensors, low-power processing, and activity modeling have enabled applications that use on-body sensing and machine learning to infer people's activities throughout everyday life. To address the growing rate of sedentary lifestyles, we have developed a system, UbiFit Garden, which uses these technologies and a personal, mobile display to encourage physical activity. We conducted a 3-week field trial in which 12 participants used the system and report findings focusing on their experiences with the sensing and activity inference. We discuss key implications for systems that use on-body sensing and activity inference to encourage physical activity.

Physical exercising is an essential part of any rehabilitation plan. The subject must be committed to a daily exercising routine, as well as to a frequent contact with the therapist. Rehabilitation plans can be quite expensive and time-consuming. On the other hand, tele-rehabilitation systems can be really helpful and efficient for both subjects and therapists. In this paper, we present ReAdapt, an adaptive module for a tele-rehabilitation system that takes into consideration the progress and performance of the exercising utilizing multisensing data and adjusts the session difficulty resulting to a personalized session. Multimodal data such as speech, facial expressions and body motion are being collected during the exercising and feed the system to decide on the exercise and session difficulty. We formulate the problem as a Markov Decision Process and apply a Reinforcement Learning algorithm to train and evaluate the system on simulated data.

Our goal is to automate the understanding of natural hand-object manipulation by developing computer visionbased techniques. Our hypothesis is that it is necessary to model the grasp types of hands and the attributes of manipulated objects in order to accurately recognize manipulation actions. Specifically, we focus on recognizing hand grasp types, object attributes and actions from a single image within an unified model. First, we explore the contextual relationship between grasp types and object attributes, and show how that context can be used to boost the recognition of both grasp types and object attributes. Second, we propose to model actions with grasp types and object attributes based on the hypothesis that grasp types and object attributes contain complementary information for characterizing different actions. Our proposed action model outperforms traditional appearance-based models which are not designed to take into account semantic constraints such as grasp types or object attributes. Experiment results on public egocentric activities datasets strongly support our hypothesis.

Both recognizing human behavior and understanding a user's mobility from sensor data are critical issues in ubiquitous computing systems. As a kind of user behavior, the transportation modes, such as walking, driving, etc., that a user takes, can enrich the user's mobility with informative knowledge and provide pervasive computing systems with more context information. In this paper, we propose an approach based on supervised learning to infer people's motion modes from their GPS logs. The contribution of this work lies in the following two aspects. On one hand, we identify a set of sophisticated features, which are more robust to traffic condition than those other researchers ever used. On the other hand, we propose a graph-based post-processing algorithm to further improve the inference performance. This algorithm considers both the commonsense constraint of real world and typical user behavior based on location in a probabilistic manner. Using the GPS logs collected by 65 people over a period of 10 months, we evaluated our approach via a set of experiments. As a result, based on the change point-based segmentation method and Decision Tree-based inference model, the new features brought an eight percent improvement in inference accuracy over previous result, and the graph-based post-processing achieve a further four percent enhancement.

This paper proposes amulti-level feature learning framework for human action recognition using a single body-worn inertial sensor. The framework consists of three phases, respectively designed to analyze signal-based (low-level), components (mid-level) and semantic (high-level) information. Low-level features capture the time and frequency domain property while mid-level representations learn the composition of the action. The Maxmargin Latent Pattern Learning (MLPL) method is proposed to learn high-level semantic descriptions of latent action patterns as the output of our framework. The proposedmethod achieves the state-of-the-art performances, 88.7%, 98.8% and 72.6% (weighted F1 score) respectively, on Skoda, WISDM and OPP datasets. © 2017 Elsevier B.V. All rights reserved.

Training and handling working dogs is a costly process and requires specialized skills and techniques. Less subjective and lower-cost training techniques would not only improve our partnership with these dogs but also enable us to benefit from their skills more efficiently. To facilitate this, we are developing a canine body-area-network (cBAN) to combine sensing technologies and computational modeling to provide handlers with a more accurate interpretation for dog training. As the first step of this, we used inertial measurement units (IMU) to remotely detect the behavioral activity of canines. Decision tree classifiers and Hidden Markov Models were used to detect static postures (sitting, standing, lying down, standing on two legs and eating off the ground) and dynamic activities (walking, climbing stairs and walking down a ramp) based on the heuristic features of the accelerometer and gyroscope data provided by the wireless sensing system deployed on a canine vest. Data was collected from 6 Labrador Retrievers and a Kai Ken. The analysis of IMU location and orientation helped to achieve high classification accuracies for static and dynamic activity recognition.

This paper presents an Internet of Things (IoT) approach to Human Activity Recognition (HAR) using remote monitoring of vital signs in the context of a healthcare system for self-managed chronic heart patients. Our goal is to create a HAR-IoT system using learning algorithms to infer the activity done within 4 categories (lie, sit, walk and run) as well as the time consumed performing these activities and, finally giving feedback during and after the activity. Alike in this work, we provide a comprehensive insight on the cloud-based system implemented and the conclusions after implementing two different learning algorithms and the results of the overall system for larger implementations.

This paper proposes an algorithm for fall detection using a ceiling-mounted 3D depth camera. The lying pose is separated from common daily activities by a k-NN classifier, which was trained on features expressing head-floor distance, person area and shape's major length to width. In order to distinguish between intentional lying postures and accidental falls the algorithm also employs motion between static postures. The experimental validation of the algorithm was conducted on realistic depth image sequences of daily activities and simulated falls. It was evaluated on more than 45000 depth images and gave 0% error. To reduce the processing overload an accelerometer was used to indicate the potential impact of the person and to start an analysis of depth images.

We present FinDroidHR, a novel gesture input technique for off-the-shelf smartwatches. Our technique is designed to detect 10 hand gestures on the hand wearing a smartwatch. The technique is enabled by analysing features of the Photoplethysmography (PPG) signal that optical heart-rate sensors capture. In a study with 20 participants, we show that FinDroidHR achieves 90.55% accuracy and 90.73% recall. Our work is the first study to explore the feasibility of using optical sensors on the off-the-shelf wearable devices to recognise gestures. Without requiring bespoke hardware, FinDroidHR can be readily used on existing smartwatches.

While indoor portable navigation using portable devices is becoming increasingly required, it faces many challenges in obtaining accurate positioning performance. One of the methods to improve navigation results is to recognize the mode of motion of the user carrying the portable device containing low-cost microelectromechanical systems (MEMS) motion sensors. Pattern recognition methodology has been employed to detect a group of motion modes that are common indoors, namely, walking, stationary, going up/down stairs, standing on an escalator, walking on an escalator, standing on a moving walkway, and walking on a moving walkway. The performance of the motion mode recognition module was examined on different types of mobile computing devices, including various brands of smartphones, tablets, smartwatches, and smartglasses, and the results obtained showed the capability of enhancing positioning performance. The module does not require satellite or wireless positioning signals, and depends only on MEMS sensors.


Question: Recognition of daily routines through the identification of specific activities.

This paper explores the application of Support Vector Machines (SVMs) in the realm of computer vision, specifically for the task of face detection. SVMs, a learning technique pioneered by V. Vapnik and his team at AT&T Bell Labs, offer a novel approach to training classifiers such as polynomial, neural network, or Radial Basis Functions. The core mechanism of SVMs involves solving a linearly constrained quadratic programming problem to identify decision surfaces. However, this optimization challenge is significant due to the quadratic form's density and the memory demands that scale quadratically with the number of data points. To address these limitations, the authors introduce a decomposition algorithm designed to ensure global optimality, capable of training SVMs on large datasets. The algorithm's strategy revolves around iteratively solving sub-problems and evaluating optimality conditions, which not only improve the iterative values but also define the stopping criteria. The effectiveness of this SVM implementation is demonstrated through experimental results on a face detection task, involving a dataset of 50,000 data points, thereby validating the practicality and efficiency of the approach.

**Question**: The Role of Technology in Enhancing Learning Outcomes

**Documents**: The Effect of Mobile Learning on Student Engagement and Academic Performance
This study examines the impact of mobile learning on student engagement and academic performance in a higher education setting. Mobile learning, defined as the use of mobile devices for learning purposes, has gained popularity due to the ubiquity of smartphones and tablets. The study involved 100 undergraduate students enrolled in a mathematics course at a university in the United States. The students were randomly assigned to two groups: the experimental group, which used a mobile learning application for course material, and the control group, which received traditional classroom instruction. The mobile learning application provided interactive lessons, quizzes, and access to course materials via smartphones. Student engagement was measured using a self-report survey, while academic performance was assessed through course grades. Results showed that the experimental group had significantly higher levels of engagement and academic performance compared to the control group. The findings suggest that mobile learning can enhance student engagement and improve academic performance in higher education.

**Similar Documents**: This research investigates the influence of mobile learning on student engagement and academic performance within a higher education context. Mobile learning, characterized by the utilization of mobile devices for educational purposes, has surged in popularity given the widespread use of smartphones and tablets. The study engaged 100 undergraduate students enrolled in a mathematics course at a university in the United States. Participants were divided into two groups: an experimental group

The potential of the artificial intelligence, data mining and the so-called Big Data to build solutions based on the understanding of human behaviours is being extended with the capabilities of the Future Internet and the Internet of Things (IoT). The described potential of data and networks have been analyzed by the complex network theory, offering a specialized branch, the defined as Human Dynamics. The goal with the Internet of Things in the social area is to describe in real-time the human behaviours and activities. These goals are starting to be feasible through the quantity of data provided by the personal devices such as smart phone, and the smart environments such as Smart cities that makes more intelligent the environment and offer a smart space that sense our movements, actions, and the evolution of the ecosystem. This work analyses the ecosystem defined through the triangle formed by Big Data, Smart Cities and Personal/Wearable Computing to determinate human behaviours and human dynamics. For this purpose, the life-cycle of human dynamics determinations in Smart Cities have been analysed in order to determinate the current status of the technology, challenges, and opportunities.

This paper introduces a human posture tracking platform to identify the human postures of sitting, standing or lying down, based on a smartwatch. This work develops such a system as a proof-of-concept study to investigate a smartwatch's ability to be used in future remote health monitoring systems and applications. This work validates the smartwatches' ability to track the posture of users accurately in a laboratory setting while reducing the sampling rate to potentially improve battery life, the first steps in verifying that such a system would work in future clinical settings. The algorithm developed classifies the transitions between three posture states of sitting, standing and lying down, by identifying these transition movements, as well as other movements that might be mistaken for these transitions. The system is trained and developed on a Samsung Galaxy Gear smartwatch, and the algorithm was validated through a leave-one-subject-out cross-validation of 20 subjects. The system can identify the appropriate transitions at only 10 Hz with an F-score of 0.930, indicating its ability to effectively replace smart phones, if needed.

We introduce a problem class which we term activity monitoring. Such problems involve monitoring the behavior of a large population of entities for interesting events requiring action. We present a framework within which each of the individual problems has a natural expression, as well as a methodology for evaluating performance of activity monitoring techniques. We show that two superficially different tasks, news story monitoring and intrusion detection, can be expressed naturally within the framework, and show that key differences in solution methods can be compared.

In urban public transport, smart card data is made of millions of observations of users boarding vehicles over the network across several days. The issue addresses whether data mining techniques can be used to study user behaviour from these observations. This must be done with the help of transportation planning knowledge. Hence, this paper presents a common “transportation planning/data mining” methodology for user behaviour analysis. Experiments were conducted on data from a Canadian transit authority. This experience demonstrates that a combination of planning knowledge and data mining tool allows producing travel behaviours indicators, mainly regarding regularity and daily patterns, from data issued from operational and management system. Results show that the public transport users of this study can rapidly be divided in four major behavioural groups, whatever type of ticket they use. Copyright © 2006 IFAC.

One of the most important challenges in chronic disease self-management is medication non-adherence, which has irrevocable outcomes. Although many technologies have been developed for medication adherence monitoring, the reliability and cost-effectiveness of these approaches are not well understood to date. This paper presents a medication adherence monitoring system by user-activity tracking based on wrist-band wearable sensors. We develop machine learning algorithms that track wrist motions in real-time and identify medication intake activities. We propose a novel data analysis pipeline to reliably detect medication adherence by examining single-wrist motions. Our system achieves an accuracy of 78.3% in adherence detection without need for medication pillboxes and with only one sensor worn on either of the wrists. The accuracy of our algorithm is only 7.9% lower than a system with two sensors that track motions of both wrists.

Sensors in everyday devices, such as our phones, wearables, and computers, leave a stream of digital traces. Personal sensing refers to collecting and analyzing data from sensors embedded in the context of daily life with the aim of identifying human behaviors, thoughts, feelings, and traits. This article provides a critical review of personal sensing research related to mental health, focused principally on smartphones, but also including studies of wearables, social media, and computers. We provide a layered, hierarchical model for translating raw sensor data into markers of behaviors and states related to mental health. Also discussed are research methods as well as challenges, including privacy and problems of dimensionality. Although personal sensing is still in its infancy, it holds great promise as a method for conducting mental health research and as a clinical tool for monitoring at-risk populations and providing the foundation for the next generation of mobile health (or mHealth) interventions.

The possibility of automatic understanding of customers’ shopping behavior and acting according to their needs is relevant in the marketing domain, attracting a lot of attention lately. In this work, we focus on the task of automatic assessment of customers’ shopping behavior, by proposing a multilevel framework. The framework is supported at low-level by different types of cameras, which are synchronized, facilitating efficient processing of information. A fish-eye camera is used for tracking, while a high-definition one serves for the action recognition task. The experiments are performed on both laboratory and real-life recordings in a supermarket. From the video recordings, we extract features related to the spatio-temporal behavior of trajectories, the dynamics and the time spent in each region of interest (ROI) in the shop and regarding the customer-products interaction patterns. Next ∗Corresponding Author. Phone: +31(0)15 2781537. Fax: +31(0)15 2787141. Email address: m.c.popa@tudelft.nl (M.C. Popa) Preprint submitted to Pattern Recognition Letters December 24, 2011 we analyze the shopping sequences using a Hidden Markov Model (HMM). We conclude that it is possible to accurately classify trajectories (93%), discriminate between different shopping related actions (91.6%), and recognize shopping behavioral types by means of the proposed reasoning model in 95% of the cases.

The ability to generalise towards either new users or unforeseen behaviours is a key requirement for activity recognition systems in ubiquitous computing. Differences in recognition performance for the two application cases can be significant, and user-dependent performance is typically assumed to be an upper bound on performance. We demonstrate that this assumption does not hold for the widely used cross-validation evaluation scheme that is typically employed both during system bootstrapping and for reporting results. We describe how the characteristics of segmented time-series data render random cross-validation a poor fit, as adjacent segments are not statistically independent. We develop an alternative approach -- meta-segmented cross validation -- that explicitly circumvents this issue and evaluate it on two data-sets. Results indicate a significant drop in performance across a variety of feature extraction and classification methods if this bias is removed, and that prolonged, repetitive activities are particularly affected.

An important aspect of human perception is anticipation and anticipating which activities will a human do next (and how to do them) in useful for many applications, for example, anticipation enables an assistive robot to plan ahead for reactive responses in the human environments. In this work, we present a constructive approach for generating various possible future human activities by reasoning about the rich spatial-temporal relations through object affordances. We represent each possible future using an anticipatory temporal conditional random field (ATCRF) where we sample the nodes and edges corresponding to future object trajectories and human poses from a generative model. We then represent the distribution over the potential futures using a set of constructed ATCRF particles. In extensive evaluation on CAD-120 human activity RGB-D dataset, for new subjects (not seen in the training set), we obtain an activity anticipation accuracy (defined as whether one of top three predictions actually happened) of 75.4%, 69.2% and 58.1% for an anticipation time of 1, 3 and 10 seconds respectively. 1

Gesture-based interaction, as a natural way for human-computer interaction, has a wide range of applications in ubiquitous computing environment. This paper presents an acceleration-based gesture recognition approach, called FDSVM (Frame-based Descriptor and multi-class SVM), which needs only a wearable 3-dimensional accelerometer. With FDSVM, firstly, the acceleration data of a gesture is collected and represented by a frame-based descriptor, to extract the discriminative information. Then a SVM-based multi-class gesture classifier is built for recognition in the nonlinear gesture feature space. Extensive experimental results on a data set with 3360 gesture samples of 12 gestures over weeks demonstrate that the proposed FDSVM approach significantly outperforms other four methods: DTW, Naïve Bayes, C4.5 and HMM. In the user-dependent case, FDSVM achieves the recognition rate of 99.38% for the 4 direction gestures and 95.21% for all the 12 gestures. In the user-independent case, it obtains the recognition rate of 98.93% for 4 gestures and 89.29% for 12 gestures. Compared to other accelerometer-based gesture recognition approaches reported in literature FDSVM gives the best resulrs for both user-dependent and user-independent cases.


Question: Identification of tumor-associated copy number alterations in the bloodstream of prostate cancer patients through whole-genome sequencing.

This study delves into the genomic and transcriptomic landscape of lethal castration-resistant prostate cancer (CRPC), revealing chromosomal rearrangements, copy number alterations, and mutations that contribute to cancer progression. Despite the identification of key genetic events such as ETS gene family fusions, PTEN loss, and AR amplification, the role of mutations in CRPC has been less explored. The research involved sequencing the exomes of 50 metastatic CRPC tumors from patients who had undergone rapid autopsy, including multiple foci from the same patient, and 11 high-grade localized prostate cancers that were treatment-naive. The findings indicated a low mutation rate, even in tumors heavily impacted by treatment, with an average of 2.00 mutations per megabase. The study confirmed the monoclonal origin of lethal CRPC and uncovered disruptions in CHD1, which characterize a subtype of ETS gene family fusion-negative prostate cancer. ETS2, often deleted in CRPC through TMPRSS2:ERG fusions, was found to be deregulated through mutation. Recurrent mutations in genes involved in chromatin and histone modification, such as MLL2 (8.6% of prostate cancers), were identified, along with the interaction of the MLL complex with the AR, essential for AR-mediated signaling. Novel recurrent mutations in FOXA1, a factor that collaborates with the AR, were found in 3.4% of prostate cancers (both untreated localized prostate cancer and CRPC), and these mutations were shown to suppress androgen signaling and enhance tumor growth. Proteins that interact with the AR, including the ERG gene fusion product, FOXA1, MLL2, UTX (also known as KDM6A), and ASXL1, were found to be mutated in CRPC. This comprehensive analysis describes the mutational landscape of heavily treated metastatic prostate cancer, uncovers new mechanisms of AR signaling deregulation in prostate cancer, and highlights potential targets for future research.

In summary, the study offers insights into the genetic alterations that drive lethal CRPC, identifying novel mutations and mechanisms that disrupt AR signaling and contribute to cancer progression. By integrating exome sequencing, copy number analysis, and functional studies, the research contributes to a deeper understanding of the molecular basis of CRPC and identifies potential therapeutic targets.

We present a concept and formalism, the string graph, which represents all that is inferable about a DNA sequence from a collection of shotgun sequencing reads collected from it. We give time and space efficient algorithms for constructing a string graph given the collection of overlaps between the reads and, in particular, present a novel linear expected time algorithm for transitive reduction in this context. The result demonstrates that the decomposition of reads into kmers employed in the de Bruijn graph approach described earlier is not essential, and exposes its close connection to the unitig approach we developed at Celera. This paper is a preliminary piece giving the basic algorithm and results that demonstrate the efficiency and scalability of the method. These ideas are being used to build a next-generation whole genome assembler called BOA (Berkeley Open Assembler) that will easily scale to mammalian genomes.

Objective: To evaluate the use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer.Design: An observational study assessing the nutritional status of patients with cancer.Setting: Oncology ward of a private tertiary Australian hospital.Subjects: Seventy-one cancer patients aged 18–92 y.Intervention: Scored PG-SGA questionnaire, comparison of scored PG-SGA with subjective global assessment (SGA), sensitivity, specificity.Results: Some 24% (17) of 71 patients were well nourished, 59% (42) of patients were moderately or suspected of being malnourished and 17% (12) of patients were severely malnourished according to subjective global assessment (SGA). The PG-SGA score had a sensitivity of 98% and a specificity of 82% at predicting SGA classification. There was a significant difference in the median PG-SGA scores for each of the SGA classifications (P<0.001), with the severely malnourished patients having the highest scores. Re-admission within 30 days of discharge was significantly different between SGA groups (P=0.037). The mortality rate within 30 days of discharge was not significantly different between SGA groups (P=0.305). The median length of stay of well nourished patients (SGA A) was significantly lower than that of the malnourished (SGA B+C) patients (P=0.024).Conclusion: The scored PG-SGA is an easy to use nutrition assessment tool that allows quick identification and prioritisation of malnutrition in hospitalised patients with cancer.Sponsors: The Wesley Research Institute.

A new approach to predicting the Y-chromosome haplogroup from a set of Y-STR marker values is presented and compared to other approaches. The method has been implemented in an Excel-based program, where an arbitrary number of STR markers may be input and a “goodness of fit” score for 10 haplogroups (E3a, E3b, G, I1a, I1b, I1c, J2, N3, R1a, and R1b) is returned. This method has been applied to 101 R1b haplotypes and 50 I1a haplotypes (all having 37 STR markers available), and the distribution of results is presented. In the case of I1a, the results are compared with the predictions of another method.

The next-generation sequencing technologies provide a great deal of transcripts for bioinformatics research. Specially, because of the regulation of long non-coding RNAs (lncRNAs) in various cellular processes, the research on IncRNAs is in full swing. And the solution of IncRNAs identification is the basis for the in-depth study of its functions. In this study, we present an approach to identify the IncRNAs from large scale transcripts, named IncDML which is completely different from previous identification methods. In our model, we extract signal to noise ratio (SNR) and k-mer from transcripts sequences as features. Firstly, we just use the SNR to cluster the original dataset to three parts. In this process, we achieve preliminary identification effect to some extent. Then abandoning traditional feature selection, we directly measure the relationship between each pair of samples by deep metric learning for each part of data. Finally, a novel classifier based on complex network is applied to achieve the final identification. The experiment results show that IncDML is a very effective method for identifying IncRNAs.

To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. High-risk prostate cancer patients (n=28) underwent simultaneous 18F-fluciclovine PET/MRI prior to surgery. LNs were removed according to a predefined template of eight regions. PET and MR images were evaluated for presence of LN metastases according to these regions. Sensitivity/specificity for detection of LN metastases were calculated on patient and region basis. Sizes of LN metastases in regions with positive and negative imaging findings were compared with linear mixed models. Clinical parameters of PET-positive and -negative stage N1 patients were compared with the Mann-Whitney U test. Patient- and region-based sensitivity/specificity for detection of pelvic LN metastases was 40 %/87.5 % and 35 %/95.7 %, respectively, for MRI and 40 %/100 % and 30 %/100 %, respectively, for PET. LN metastases in true-positive regions were significantly larger than metastases in false-negative regions. PET-positive stage N1 patients had higher metastatic burden than PET-negative N1 patients. Simultaneous 18F-fluciclovine PET/MRI provides high specificity but low sensitivity for detection of LN metastases in high-risk prostate cancer patients. 18F-Fluciclovine PET/MRI scan positive for LN metastases indicates higher metastatic burden than negative scan. • 18 F-Fluciclovine PET/MRI has high specificity for detection of lymph node metastasis. • 18 F-Fluciclovine PET/MRI lacks sensitivity to replace ePLND. • 18 F-Fluciclovine PET/MRI may be used to aid surgery and select adjuvant therapy. • 18 F-Fluciclovine PET-positive patients have more extensive disease than PET-negative patients. • Size of metastatic lymph nodes is an important factor for detection.

The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The "Rhineland hypothesis" depicts Eastern European Jews as a "population isolate" that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the "Khazarian hypothesis" suggests that Eastern European Jews descended from the Khazars, an amalgam of Turkic clans that settled the Caucasus in the early centuries CE and converted to Judaism in the 8th century. Mesopotamian and Greco-Roman Jews continuously reinforced the Judaized empire until the 13th century. Following the collapse of their empire, the Judeo-Khazars fled to Eastern Europe. The rise of European Jewry is therefore explained by the contribution of the Judeo-Khazars. Thus far, however, the Khazars' contribution has been estimated only empirically, as the absence of genome-wide data from Caucasus populations precluded testing the Khazarian hypothesis. Recent sequencing of modern Caucasus populations prompted us to revisit the Khazarian hypothesis and compare it with the Rhineland hypothesis. We applied a wide range of population genetic analyses to compare these two hypotheses. Our findings support the Khazarian hypothesis and portray the European Jewish genome as a mosaic of Near Eastern-Caucasus, European, and Semitic ancestries, thereby consolidating previous contradictory reports of Jewish ancestry. We further describe a major difference among Caucasus populations explained by the early presence of Judeans in the Southern and Central Caucasus. Our results have important implications for the demographic forces that shaped the genetic diversity in the Caucasus and for medical studies.

Evidence for the etiology of autism spectrum disorders (ASDs) has consistently pointed to a strong genetic component complicated by substantial locus heterogeneity. We sequenced the exomes of 20 individuals with sporadic ASD (cases) and their parents, reasoning that these families would be enriched for de novo mutations of major effect. We identified 21 de novo mutations, 11 of which were protein altering. Protein-altering mutations were significantly enriched for changes at highly conserved residues. We identified potentially causative de novo events in 4 out of 20 probands, particularly among more severely affected individuals, in FOXP1, GRIN2B, SCN1A and LAMC3. In the FOXP1 mutation carrier, we also observed a rare inherited CNTNAP2 missense variant, and we provide functional support for a multi-hit model for disease risk. Our results show that trio-based exome sequencing is a powerful approach for identifying new candidate genes for ASDs and suggest that de novo mutations may contribute substantially to the genetic etiology of ASDs.

microRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate the expression of a large fraction of all animal genes and are important in a wide range of biological processes. Recent advances in high-throughput sequencing allow miRNA detection at unprecedented sensitivity, but the computational task of accurately identifying the miRNAs in the background of sequenced RNAs remains challenging. For this purpose, we have designed miRDeep2, a substantially improved algorithm which identifies canonical and non-canonical miRNAs such as those derived from transposable elements and informs on high-confidence candidates that are detected in multiple independent samples. Analyzing data from seven animal species representing the major animal clades, miRDeep2 identified miRNAs with an accuracy of 98.6-99.9% and reported hundreds of novel miRNAs. To test the accuracy of miRDeep2, we knocked down the miRNA biogenesis pathway in a human cell line and sequenced small RNAs before and after. The vast majority of the >100 novel miRNAs expressed in this cell line were indeed specifically downregulated, validating most miRDeep2 predictions. Last, a new miRNA expression profiling routine, low time and memory usage and user-friendly interactive graphic output can make miRDeep2 useful to a wide range of researchers.

Finding genes that are differentially expressed between conditions is an integral part of understanding the molecular basis of phenotypic variation. In the past decades, DNA microarrays have been used extensively to quantify the abundance of mRNA corresponding to different genes, and more recently high-throughput sequencing of cDNA (RNA-seq) has emerged as a powerful competitor. As the cost of sequencing decreases, it is conceivable that the use of RNA-seq for differential expression analysis will increase rapidly. To exploit the possibilities and address the challenges posed by this relatively new type of data, a number of software packages have been developed especially for differential expression analysis of RNA-seq data. We conducted an extensive comparison of eleven methods for differential expression analysis of RNA-seq data. All methods are freely available within the R framework and take as input a matrix of counts, i.e. the number of reads mapping to each genomic feature of interest in each of a number of samples. We evaluate the methods based on both simulated data and real RNA-seq data. Very small sample sizes, which are still common in RNA-seq experiments, impose problems for all evaluated methods and any results obtained under such conditions should be interpreted with caution. For larger sample sizes, the methods combining a variance-stabilizing transformation with the ‘limma’ method for differential expression analysis perform well under many different conditions, as does the nonparametric SAMseq method.

Technology development in biological research often aims to either increase the number of cellular features that can be surveyed simultaneously or enhance the resolution at which such observations are possible. For decades, flow cytometry has balanced these goals to fill a critical need by enabling the measurement of multiple features in single cells, commonly to examine complex or hierarchical cellular systems. Recently, a format for flow cytometry has been developed that leverages the precision of mass spectrometry. This fusion of the two technologies, termed mass cytometry, provides measurement of over 40 simultaneous cellular parameters at single-cell resolution, significantly augmenting the ability of cytometry to evaluate complex cellular systems and processes. In this Primer, we review the current state of mass cytometry, providing an overview of the instrumentation, its present capabilities, and methods of data analysis, as well as thoughts on future developments and applications.


Question: Identification of tumor-associated copy number alterations in the bloodstream of prostate cancer patients through whole-genome sequencing.

This paper explores the potential of utilizing circulating mutant DNA as a tool for monitoring tumor dynamics in cancer patients, akin to the use of circulating nucleic acids in managing chronic viral infections like HIV. The specificity of DNA containing somatic mutations, which are highly indicative of tumor presence, suggests their potential as superior markers for cancer surveillance. However, the challenge lies in the low abundance of circulating mutant gene fragments relative to normal circulating DNA, necessitating highly sensitive detection methods for clinical utility. In this study, we employed an advanced, sensitive method to quantify circulating tumor DNA (ctDNA) in 162 plasma samples from 18 colorectal cancer patients undergoing various treatment modalities. Our findings revealed that ctDNA measurements could effectively track tumor response and progression in patients undergoing surgery or chemotherapy. We propose that this personalized genomic approach could be broadly applicable to cancer patients of different types, offering a non-invasive means to monitor disease status and treatment efficacy (pages 914–915).

Sequence pattern mining aims to discover frequent subsequences as patterns in a single sequence or a sequence database. By combining gap constraints (or flexible wildcards), users can specify special characteristics of the patterns and discover meaningful subsequences suitable for their own application domains, such as finding gene transcription sites from DNA sequences or discovering patterns for time series data classification. Due to the inherent complexity of sequence patterns, including the exponential candidate space with respect to pattern letters and gap constraints, to date, existing sequence pattern mining methods are either incomplete or do not support the Apriori property because the support ratio of a pattern may be greater than that of its subpatterns. Most importantly, patterns discovered by these methods are either too restrictive or too general and cannot represent underlying meaningful knowledge in the sequences. In this paper, we focus on a nonoverlapping sequence pattern mining task with gap constraints, where a nonoverlapping sequence pattern allows sequence letters to be flexibly and maximally utilized for pattern discovery. A new Apriori-based nonoverlapping sequence pattern mining algorithm, NOSEP, is proposed. NOSEP is a complete pattern mining algorithm, which uses a specially designed data structure, Nettree, to calculate the exact occurrence of a pattern in the sequence. Experimental results and comparisons on biology DNA sequences, time series data, and Gazelle datasets demonstrate the efficiency of the proposed algorithm and the uniqueness of nonoverlapping sequence patterns compared to other methods.

The emergence of next-generation sequencing platforms led to resurgence of research in whole-genome shotgun assembly algorithms and software. DNA sequencing data from the Roche 454, Illumina/Solexa, and ABI SOLiD platforms typically present shorter read lengths, higher coverage, and different error profiles compared with Sanger sequencing data. Since 2005, several assembly software packages have been created or revised specifically for de novo assembly of next-generation sequencing data. This review summarizes and compares the published descriptions of packages named SSAKE, SHARCGS, VCAKE, Newbler, Celera Assembler, Euler, Velvet, ABySS, AllPaths, and SOAPdenovo. More generally, it compares the two standard methods known as the de Bruijn graph approach and the overlap/layout/consensus approach to assembly.

Background:There is variability in the cancer phenotype across individuals: two patients with the same tumour may experience different disease life histories, resulting from genetic variation within the tumour and from the interaction between tumour and host. Until now, phenotypic variability has precluded a clear-cut identification of the fundamental characteristics of a given tumour type.Methods:Using multiple myeloma as an example, we apply the principles of evolutionary game theory to determine the fundamental characteristics that define the phenotypic variability of a tumour.Results:Tumour dynamics is determined by the frequency-dependent fitness of different cell populations, resulting from the benefits and costs accrued by each cell type in the presence of others. Our study shows how the phenotypic variability in multiple myeloma bone disease can be understood through the theoretical approach of a game that allows the identification of key genotypic features in a tumour and provides a natural explanation for phenotypic variability. This analysis also illustrates how complex biochemical signals can be translated into cell fitness that determines disease dynamics.Conclusion:The present paradigm is general and extends well beyond multiple myeloma, and even to non-neoplastic disorders. Furthermore, it provides a new perspective in dealing with cancer eradication. Instead of trying to kill all cancer cells, therapies should aim at reducing the fitness of malignant cells compared with normal cells, allowing natural selection to eradicate the tumour.

n engl j med 363;4 nejm.org july 22, 2010 301 to human illness, identified genetic variability in patients’ responses to dozens of treatments, and begun to target the molecular causes of some diseases. In addition, scientists are developing and using diagnostic tests based on genetics or other molecular mechanisms to better predict patients’ responses to targeted therapy. The challenge is to deliver the benefits of this work to patients. As the leaders of the National Institutes of Health (NIH) and the Food and Drug Administration (FDA), we have a shared vision of personalized medicine and the scientific and regulatory structure needed to support its growth. Together, we have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. We recognize that myriad obstacles must be overcome to achieve these goals. These include scientific challenges, such as determining which genetic markers have the most clinical significance, limiting the off-target effects of gene-based therapies, and conducting clinical studies to identify genetic variants that are correlated with a drug response. There are also policy challenges, such as finding a level of regulation for genetic tests that both protects patients and encourages innovation. To make progress, the NIH and the FDA will invest in advancing translational and regulatory science, better define regulatory pathways for coordinated approval of codeveloped diagnostics and therapeutics, develop risk-based approaches for appropriate review of diagnostics to more accurately assess their validity and clinical utility, and make information about tests readily available. Moving from concept to clinical use requires basic, translational, and regulatory science. On the basic-science front, studies are identifying many genetic variations underlying the risks of both rare and common diseases. These newly discovered genes, proteins, and pathways can represent powerful new drug targets, but currently there is insufficient evidence of a downstream market to entice the private sector to explore most of them. To fill that void, the NIH and the FDA will The Path to Personalized Medicine

In this paper, we provide an introduction to machine learning tasks that address important problems in genomic medicine. One of the goals of genomic medicine is to determine how variations in the DNA of individuals can affect the risk of different diseases, and to find causal explanations so that targeted therapies can be designed. Here we focus on how machine learning can help to model the relationship between DNA and the quantities of key molecules in the cell, with the premise that these quantities, which we refer to as cell variables, may be associated with disease risks. Modern biology allows high-throughput measurement of many such cell variables, including gene expression, splicing, and proteins binding to nucleic acids, which can all be treated as training targets for predictive models. With the growing availability of large-scale data sets and advanced computational techniques such as deep learning, researchers can help to usher in a new era of effective genomic medicine.

We used trio-based whole-exome sequencing to analyze two families affected by Weaver syndrome, including one of the original families reported in 1974. Filtering of rare variants in the affected probands against the parental variants identified two different de novo mutations in the enhancer of zeste homolog 2 (EZH2). Sanger sequencing of EZH2 in a third classically-affected proband identified a third de novo mutation in this gene. These data show that mutations in EZH2 cause Weaver syndrome.

DisGeNET is a comprehensive discovery platform designed to address a variety of questions concerning the genetic underpinning of human diseases. DisGeNET contains over 380,000 associations between >16,000 genes and 13,000 diseases, which makes it one of the largest repositories currently available of its kind. DisGeNET integrates expert-curated databases with text-mined data, covers information on Mendelian and complex diseases, and includes data from animal disease models. It features a score based on the supporting evidence to prioritize gene-disease associations. It is an open access resource available through a web interface, a Cytoscape plugin and as a Semantic Web resource. The web interface supports user-friendly data exploration and navigation. DisGeNET data can also be analysed via the DisGeNET Cytoscape plugin, and enriched with the annotations of other plugins of this popular network analysis software suite. Finally, the information contained in DisGeNET can be expanded and complemented using Semantic Web technologies and linked to a variety of resources already present in the Linked Data cloud. Hence, DisGeNET offers one of the most comprehensive collections of human gene-disease associations and a valuable set of tools for investigating the molecular mechanisms underlying diseases of genetic origin, designed to fulfill the needs of different user profiles, including bioinformaticians, biologists and health-care practitioners. Database URL: http://www.disgenet.org/

A prototype microwave breast imaging system is used to scan a small group of patients. The prototype implements a monostatic radar-based approach to microwave imaging and utilizes ultra-wideband signals. Eight patients were successfully scanned, and several of the resulting images show responses consistent with the clinical patient histories. These encouraging results motivate further studies of microwave imaging for breast health assessment.

New analytical methodologies, like the so-called “next-generation sequencing” (NGS), allow the sequencing of full genomes with high speed and reduced price. Yet, such technologies generate huge amounts of data that demand large raw computational power. Many-core technologies can be exploited to overcome the involved bioinformatics bottleneck. Indeed, such hardware is currently in active development. We have developed parallel bioinformatics algorithms for many-core microprocessors containing 64 cores each. Thus, the MC64 web platform allows executing high-performance alignments (NeedlemanWunsch, Smith-Waterman and ClustalW) of long sequences. The MC64 platform can be accessed via web browsers, allowing easy resource integration into thirdparty tools. Furthermore, the results obtained from the MC64 include timeperformance statistics that can be compared with other platforms.

We present a deep learning framework for computer-aided lung cancer diagnosis. Our multi-stage framework detects nodules in 3D lung CAT scans, determines if each nodule is malignant, and nally assigns a cancer probability based on these results. We discuss the challenges and advantages of our framework. In the Kaggle Data Science Bowl 2017, our framework ranked 41st out of 1972 teams.